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Liane talks with NPR's Mike Shuster about the future of the US national missile defense system, in the aftermath of Friday night's test failure. Shuster says the latest failure may delay, but not ultimately derail, the deployment of the system.

Liane visits the National Institutes of Health, and talks with Dr. Alan Guttmacher of the National Human Genome Research Institute. Dr. Guttmacher tells Liane what the discovery of the genome map will mean for the future.

Puzzle master Will Shortz quizzes one of our listeners, and has a challenge for everyone at home. (This week's winner is David Slesnick from Pittsburgh, Pennsylvania. He listens to Weekend Edition on member station WDUQ.)

Liane speaks with author and regular Weekend Edition essayist Tim Brookes about his book A Hell of a Place To Lose a Cow: An American Hitchhiking Odyssey (National Geographic). In 1998 Brookes retraced the steps of a hitchhiking journey he first undertook in 1973 aged 20, shortly after he arrived in the United States from England.

The National Story Project with Paul Auster is entering its last few months. If you're planning to send us a story, the time is now! Send entries to nationalstoryproject@npr.org; or PMB 206, 123 Seventh Ave, Brooklyn, NY 11215

NPR Senior News Analyst Daniel Schorr predicts that with the Pentagon, politicians and major aerospace corporations supporting the missile defense initiative, there's a good chance that, despite the failure, pressure will continue to be exerted to keep the program going.

Weekend Edition essayist Andy Borowitz has his own personal (and humorous) take on the potential social benefits from the Human Genome map.

Host Bob Edwards talks with commentator John Feinstein about tonight's Major League All Star Game in Atlanta. The festivities began last night at Turner Field, when Sammy Sosa defeated Ken Griffey Junior to win the Home Run Derby.

NPR's Ina Jaffe reports that a fourth police officer has been charged with misconduct in the ongoing probe of corruption in the Los Angeles Police Department. New charges have also been filed against two of three officers already facing trial.

From member station WSHU, Tandaleya Wilder reports that private parks and beaches in Greenwich, Connecticut may soon be open to the public. Many in the upscale community, which is on the outskirts of New York City, argue that opening their beaches and parks to non-residents would be disastrous.

Commentator Matt Miller says, he has an idea that will save Television executives from airing boring programs and serve a societal purpose. If death penalty fans consider capital punishment to be a deterrent, he says, airing executions should persuade people not to kill one another.

Host Bob Edwards talks to John Bogle a personal finance pioneer and founder of the Vanguard Group, about mutual funds. Bogle criticizes the management practices of mutual funds and provides advise for consumers who are interested in investing in these funds.